Evaluation of Dynamic Changes of IgG and IgM in COVID-19 Patients by Different Detection Methods

Objective: To analyze the dynamic evaluation of chemiluminescence, colloidal gold, and immunofluorescence chromatography in detecting antibodies COVID-19 patients within four weeks infection, to provide evidence for clinical application. Method: 74 with confirmed SARS-COV-2 infection local area were selected as experimental group, while 231 negative results but not vaccinated Covid19 vaccine control group; during first, second, third, fourth after enrollment three methods used detect IgG IgM patients’ blood: chemiluminescence method, gold antibody immuno-fluorescence chromatography. In physical examination nucleic acids. The ROC curve was drawn value each indicator predicting kappa method consistency detection indicator. Results: There no significant difference positive rates detected by four-week period (P > 0.05). first week higher than 60%; when vivo, AUC diagnosed test less 0.80 at week, diagnostic efficacy above 0.95 from second 0.97 week. comparable; showed high cycles. Conclusion: Chemiluminescence, are highly consistent antibodies, can be an auxiliary diagnosis observation novel coronavirus infections according needs, rate infected people is low.